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Selected publications below (click icons above for full bibliography / Milnerwood profile)

Volpicelli-Daley LA, Abdelmotilib H, Liu Z, Stoyka L, Daher JP, Milnerwood AJ, Unni VK, Hirst WD, Yue Z, Zhao HT, Fraser K, Kennedy RE, West AB.(2016) G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons. J Neurosci.


Volta M., Cataldi, S., Beccano-Kelly D.A., Munsie L.N., Tatarnikov I., Chou P., Bergeron S., Mitchell E., Lim R., Khinda, J., Lloret A., Bennett C.F., Paradiso C., Morari M., Farrer M.J. & Milnerwood A.J. (2015) Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release. Parkin. & Rel. dis.


Volta M, Milnerwood AJ, Farrer MJ. (2015) Insights from late-onset familial parkinsonism on the pathogenesis of idiopathic Parkinson's disease. Lancet Neurol

Beccano-Kelly D.A., Volta M., Munsie L.N., Paschall S. A., Tatarnikov I., Co K., Chou P., Cao L.P., Bergeron S., Mitchell E., Han H., Melrose H.L., Tapia L., Raymond L.A., Farrer M.J. & Milnerwood A.J. (2015) LRRK2 overexpression alters presynaptic glutamatergic plasticity, striatal dopamine tone, postsynaptic signal transduction, behavioral activity and long-term memory. Hum Mol Gen.

Munsie L.N., Milnerwood A.J., Seibler, P. Beccano-Kelly D.A., Tatarnikov I.T., Kindah, J., Volta M., Kadgien C., Cao L.P., Tapia L. Klein C. & Farrer M.J. (2015) Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson’s Disease VPS35 mutation p.D620N. Hum Mol Gen. 

Beccano-Kelly D.A., Kuhlmann, N., Tatarnikov I., Volta M., Munsie L.N., Chou P., Cao L.P., Han H., Tapia L.,Farrer M.J. & Milnerwood A.J. (2014) Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice. Front. Cell. Neurosci. 

Brigidi G.S., Sun Y., Beccano-Kelly D.A., Pitman K., Borgland S.L., Milnerwood A.J. & Bamji S.X. Delta-catenin Palmitoylation is Essential for Activity-dependent Enhancements of Synapse Structure and Efficacy (2014). Nat Neurosci. 

Milnerwood A. J., Parsons M., Young F., Singaraja, R., Volta M., Bergeron S., Hayden, M.R. & Raymond, L. A. (2013) Cognitive deficits and severe disruption of synaptic transmission and plasticity in HIP14 palmitoyl transferase knock-out mice. PNAS 

Milnerwood A.J., *Kaufman A.M., Sepers M., Gladding C.M., Fan, J., Coquinco, A., Zhang L.Y., Wang L., Qoi J., Lee H., Cynader, M. & Raymond L.A. (2012) Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington’s disease mice.Neurobiol Dis.


Kaufman A.M., *Milnerwood A.J., Sepers M., Coquinco A., She K., Wang L., Lee H., Craig A.M., Cynader M. & Raymond L.A. (2012) Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in striatal and cortical neurons. J. Neurosci. 

Petkau T., Neal S.J., Milnerwood A. J., Mew A., Hill A.M., Orban P., Gregg J., Lu H., Feldman H.H., Mackenzie I.R.A., Raymond L.A. & Leavitt B.R. (2012). Synaptic dysfunction in progranulin-deficient mice. Neurobiol.Dis.

Tapia L., Milnerwood A. J., Guo A., Mills F., Yoshida E., Vasuta O.C, Mackenzie I., Raymond, L. A., Cynader M., Jia W., Bamji S.X. (2011). PGRN Deficiency Decreases Neural Connectivity But Enhances Synaptic Transmission at Individual Synapses. J. Neurosci.


Raymond LA, André VM, Cepeda C, Gladding CM, Milnerwood AJ, Levine MS. (2011) Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function. Neuroscience.


Milnerwood A. J. , Gladding C. M., Pouladi M. A., Kaufman A.M., Hines R. M., Boyd  J., Ko R.W.Y., Vasuta O. C., Graham R. K., Hayden M. R., Murphy T. H. & Raymond L. A. (2010). Early increase in extrasynaptic NMDA receptor signalling and expression contributes to phenotype onset in Huntington's disease mice. Neuron

Milnerwood A. J. & Raymond L. A. (2010). Early Synaptic Pathophysiology in Neurodegeneration: Insights from Huntington’s disease. Trends in Neurosciences 

Milnerwood A. J. & Raymond, L. A. (2007). Corticostriatal Synaptic Function in Mouse Models of Huntington's Disease: Early Effects of Huntingtin Repeat Length and Protein Load. J. Physiol.


Cummings D. M., Milnerwood A. J., Dallérac G.M., Vatsavayai S. C., Hirst M. C. & Murphy, K. P. (2007). Abnormal cortical synaptic plasticity in mice transgenic for human Huntington's disease mutation. Brain. Res. Bull.

Milnerwood A. J., Cummings D. M., Dallérac G.M., Brown J. Y., Vatsavayai S. C., Hirst M. C., Rezaie P. & Murphy, K. P. (2006). Early development of aberrant synaptic plasticity in a mouse model of Huntington’s disease. Hum. Mol. Gen.

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